Immunohistochemical determination of p53 overexpression
نویسندگان
چکیده
منابع مشابه
Immunohistochemical Determination of p53 Protein Overexpression for Predicting p53 Gene Mutations in Hepatocellular Carcinoma: A Meta-Analysis
BACKGROUND Whether increased expression of the tumor suppressor protein p53 indicates a p53 gene mutation in hepatocellular carcinoma (HCC) remains unclear. We conducted a meta-analysis to determine whether p53 protein overexpression detected by immunohistochemistry (IHC) offers a diagnostic prediction for p53 gene mutations in HCC patients. METHODS Systematic literature searches were conduct...
متن کاملoverexpression of p53 protein in malignant breast tumors: an immunohistochemical study
the p53 protein is expressed in all normal cells and appears to function in cell cycle regulation. abnormally higli levels of the protein are found in many different types of cancer. in breast cancer, overexpression of p53 is associated with point mutations within highly conserved regions of the p53 gene. these altered genes encode stable p53 protein that can be detected by standard immunohisto...
متن کاملPresences of human papillomavirus DNA (HPV) and immunohistochemical p53 overexpression in papillomas of oral cavity.
HPV belongs to a family of tumorigenic viruses and induces cutaneous and mucosal proliferation of epithelial cells (papillomas, condylomas, warts). The abnormality accumulation of p53 protein appears to be a common step in the development of many human cancers and has been frequently reports in human cancers including head and neck. The aim of this study was to examine HPV infection incidents a...
متن کاملp53 overexpression in refractory anemia. An immunohistochemical analysis of bone marrow biopsies.
to store iron, although hemoglobin values were on the borderline of normal. The number of HFR decreased, but not significantly. The mean values of serum ferritin in the first group of patients was 194.9±124.8 ng/mL, while it was 1091.1±733 ng/mL in the second group. We believe that the improvement shown in hematologic and reticulocyte parameters in the group of younger patients with normal seru...
متن کاملImmunohistochemical determination of five somatostatin receptors in meningioma reveals frequent overexpression of somatostatin receptor subtype sst2A.
Meningioma is one of a variety of human tumors that exhibit a very high density of somatostatin receptors and in many cases show a true positive somatostatin receptor scintigraphy. However, the level of expression of individual somatostatin receptor proteins in meningioma has not been investigated. We have recently developed a panel of somatostatin receptor subtype-specific antibodies that effe...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Urological Research
سال: 1997
ISSN: 0300-5623,1434-0879
DOI: 10.1007/bf00942045